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Prozac

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"Prozac is the most widely prescribed antidepressant in medication history.  Since it was introduced in 1986, Prozac has helped over 54 million people worldwide, including those suffering with depression, obsessive compulsive disorder, bulimia nervosa and panic disorder."
 
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Prozac (FLUOXETINE) is a Serotonin Reuptake Inhibitor (SSRI) that helps patients with depression by increasing the availability of serotonin in the brain. Scientists believe serotonin affects many types of activity in the brain, including the regulation of mood.

PROZAC by Lilly - Fluoxetine

Use:
SSRI. Depression: patients > 18 years of age - Initially, 20 mg in the morning; increase dosage gradually only after a trial period of several weeks if required. Maximum: 80 mg/day. Elderly patients: 20 mg/day. Use lower or less frequent dosage in patients with renal and/or hepatic impairment and those receiving multiple medications. When switching patients to a TCA, the TCA dosage may have to be reduced and plasma TCA concentrations may need to be monitored temporarily when
fluoxetine is coadministered or hs recently been discontinued. Bulimia nervosa: Adults, 60 mg/day. Assess electrolyte levels prior to starting therapy. Obsessive-compulsive disorder: 20 - 60 mg/day.

Prozac's long-term efficacy in bulimia (i.e., > 16 weeks) and in obsessive-compulsive disorder (i.e., > 13 weeks) has not been evaluated in controlled trials.

Precautions:
Pregnancy, lactation, patients < 18 years of age, elderly patients. History of allergic reactions, seizures, suicidal tendency, activation of mania/hypomania, MI or unstable heart disease, diabetes, severe renal or hepatic impairment, hypokalemia (following self-induced vomiting), hyponatremia, altered platelet function.

Contraindications:
Not to be used with an MAOI or within 14 days of discontinuing MAOI therapy. Allow at least 5 weeks after stopping Prozac before starting an MAOI. Do not administer thioridazine with Prozac or within 5 weeks after Prozac has been discontinued.

Safety/efficacy of combined Prozac/electroconvulsive therapy not established.

Side effects:
Headache, nervousness, insomnia, drowsiness, fatigue or asthenia, anxiety, tremor, dizziness or lightheadedness, nausea, dry mouth, diarrhea, anorexia, excessive sweating. Less frequently, rash, pruritus, weight loss, sexual dysfunction, convulsions.

Patient tips:
Full therapeutic effect may be delayed until 4 or 5 weeks of treatment. Prozac may cause drowsiness, dizziness (NB driving). Restrict alcohol intake.

Supplied:
Prozac comes in 10mg, 20 mg capsules; 20 mg/5 mL of mint-flavored syrup, 120 mL bottles.

Interactions:
See Contraindications. Warfarin (monitor PT). Lithium levels may be increased or decreased (monitor). Use cautiously with other CNS-active drugs (e.g. tryptophan), agents highly bound to plasma protein or metabolized by the P450 2D6 system. St. John's Wort (increase in undesirable effects).

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